Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.


Ying Ge, PhD

Professor, Department of Cell and Regenerative Biology
Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology

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    News and Updates

  • December 2022, Anna Grace Towler, Mallory Wilson, Matthew Fischer, Ruby Chan, and Yareslie Rivera joined our lab from the Chemistry program! Welcome to the Ge Group!
  • November 2022, Elizabeth Bayne won Best Lightening Talk and Kalina Reese won Best Poster Award at the 2nd CASMS (Chinese American Society for Mass Spectrometry) Virtual Conference. Congratulations!
  • October 2022, Elizabeth Bayne won Second Place Poster Prize at the UW-Madison Cardiovascular Research Summit!
  • September 2022, Congratulations to David Roberts for winning the graduate student Travel Award to attend the 21st World Congress of the Human Proteome Organization (HUPO 2022)!
  • June 2022, Congratulations to Eli Larson for winning the graduate student travel award for the HPLC conference!
  • April 2022, Congratulations to Bridget Knight for receiving the Eugene and Patricia Kreger Herscher Scholarship! Well done!
  • April 2022, Congratulations to Kylie Plouff for winning the Honors Summer Apprentice award! Well done!
  • March 2022, Congrats to Brad Li for receiving the Biochemistry Undergraduate Summer Research Award!
  • February 2022, Melissa Pergande is awarded the 2022 American Society for Mass Spectrometry (ASMS) Postdoc Career Development Award. Congratulations! [Link]
  • February 2022, Jake Melby is awarded the 2022 American Society for Mass Spectrometry (ASMS) Graduate Student Travel Award. Congratulations
  • February 2022, Jake Melby is awarded the 2022 Gary Parr Memorial Award from the Department of Chemistry. Congratulations!
  • February 2022, Congratulations to Elizabeth Bayne for winning the 2022 Clinical and Pharmaceutical Solutions through Analysis Steven A. Hofstadler Student Award!
  • January 2022, Jake Melby won the 2022 Chinese American Chromatography Association (CACA) Student Excellence Award. Congratulations! [Link]
  • December 2021, Holden Rogers from the Analytical Chemistry Path and Jãán Andrews from the Materials Chemistry Path joined our group. Welcome to the group!
  • December 2021, David Roberts won the 2nd place Poster Award at the 3rd Annual Cardiovascular Research Summit: Focus on Heart Failure. Congratulations David!
  • October 2021, Congratulations to Ying for making the 2021 Analytical Scientist Power List! [Link]
  • September 2021, Congrats to Ying for the HUPO 2021 Clinical and Translational Proteomics Award for her work this past decade utilizing proteomics for better patient diagnosis. [Link]
  • August 2021, Check out Ying’s interview as part of the JASMS Special Focus Issue on Top-Down Proteomics in honor of her 2020 ASMS Biemann Medal award. Congratulations again, Ying! [Link]
  • August 2021, Eli Larson and Jake Melby have each won a Poster Award at the 1st CASMS (Chinese American Society for Mass Spectrometry) Virtual Conference. Congratulations!
  • July 2021, David Roberts is awarded the 2021 ASMS (American Society for Mass Spectrometry) Graduate Student Travel Award. Congratulations!
  • May 2021, Emily Chapmen is awarded a National Institutes of Health (NIH) Chemistry-Biology Interface Training Program (CBI) Traineeship. Congrats Emily!
  • March 2021, Morgan Gugger received a Wisconsin ACS Local Section Undergraduate Award for Excellence in Chemistry! Congratulations!
  • March 2021, David Roberts is awarded a Predoctoral Fellowship from the American Heart Association! Congratulations!
  • March 2021, Kalina Reese is awarded the highly competitive NSF GRFP! Congratulations! [Link]
  • March 2021, David Roberts is awarded the 2021 Gary Parr Memorial Award from the Department of Chemistry. Congratulations!
  • March 2021, Congrats to David Roberts for winning the US HUPO 2021 Trainee Award! Well done![Link]
  • March 2021, MASH Explorer software V2.2 is available to the public. You can download the software using this link. [Link]
  • January 2021: The MASH team will be hosting an open house on Friday January 29th at 10 AM US Central Time. This open house will provide a brief introduction and discussion new features coming to v2.2 and then give users the option to attend one of three different breakout discussion rooms with members of the software development team. These breakout rooms will cover the following topics: i) Unidec in MASH for Native Top-Down MS Analysis, ii) A Tutorial for Beginning MASH Users, and iii) General Discussion for MASH Users. To attend this open house, please sign up using the form linked here. [here]
  • November 2020, MASH Explorer software V2.1 is available to the public. You can download the software using this link. [Link]
  • September 2020, Trisha and Vege's paper on using top-down proteomics to discover convergent pathways in HCM was published in PNAS! Congrats on the hard work![Link]
  • [News Release]
  • August 2020, MASH Explorer software V2.0.2 is available to the public. You can download the software using this link. [Link]
  • August 2020, MASH Explorer software V2.0.1 is available to the public. You can download the software using this link. [Link]
  • August 2020, David and Tim's paper on a nanoparticle that enriches for cardiac troponin I was published in Nature Communications! Congrats on the hard work![Link]
  • [News Release]
  • June 2020, MASH Explorer software V2.0 is available to the public. You can download the software using this link. [Link]
  • June 2020, Jake Melby is awarded a position in the Translational Cardiovascular Science T32 Predoctoral Traineeship Program. Congratulations!
  • May 2020, Morgan Gugger is awarded the Hilldale Fellowship, the Ackerman Scholarship, the Karen M. Telander Undergraduate Research Award, and the William J. Maeck Scholarship as decided by the chemistry department. Well done!
  • May 2020, Andreas Kyrvasilis is awarded the Hilldale Fellowship. Congratulations!
  • April 2020, Chance Lee Wilkinson-Johnson is awarded the Saco Polymers Scholarship and the Robert and Diane Paulick Undergraduate Scholarships. Congratulations!
  • April 2020, Ben Wancewicz is awarded the NIH F31 NRSA pre-doctoral fellowship. Well done Ben!
  • April 2020, Ying has been awarded the 2020 Biemann Medal from the American Society of Mass Spectrometry! Congratulations on this well-deserved and prestigious award! [Link]
  • March 2020, Trisha Tucholski is awarded the 2020 Gary Parr Memorial Award from the Department of Chemistry. Congratulations!
  • March 2020, Kyle Brown is awarded the 2020 Richard and Joan Hartl Excellence in Research Award from the Department of Chemistry. Congratulations!
  • Feburary 2020, Kyle Brown is awarded the 2020 ASMS (American Society for Mass Spectrometry) Graduate Student Travel Award. Congratulations!
  • January 2020, Trisha Tucholski won the 2020 CACA Student Excellence Awards in Chromatography. Congratulations!
  • January 2020, Our publication on rat skeletal muscle proteoform heterogeneity was selected for the cover of the January issue of the Journal of Proteome Research! [Link]
  • December 2019, Tim Aballo from the Molecular and Cellular Pharmacology Program has joined our lab! Welcome Tim!
  • December 2019, MASH Explorer software V1.2 is available to the public. You can download the software using this link. [Link]
  • November 2019, Emily Reasoner from the Material Chemistry Path and David Moreno from the Organic Chemistry Path joined our group. Welcome to the group!
  • October 2019, Graduate student Trisha Tucholski won the highly competitive Lake Louise Travel Award. She will be attending the 32nd Annual Mass Spectrometry Workshop in Alberta, Canada. Congrats to Trisha!
  • October 2019, Our paper was accepted in Circulation Research after a long review process! Congrats to all of the authors! [Link]
  • July 2019, MASH Explorer software is available to the public. You can download the software using this link. [Link]
  • June 2019, Dr. Bifan Chen and Dr. Yutong Jin have left our research group. Bifan will be joining Genentech and Yutong will be working for Biogen. They will for sure be missed by our lab members! [Photos]
  • June 2019, The Ge Group attended the 2019 ASMS Conference in Atlanta, GA! [Photos]
  • May 2019, The Ge Group celebrated Dr. Bifan Chen's and Dr. Yuton Jin's graduation! Congratulations to you both! [Photos]
  • May 2019, Follow us on Twitter at @Ge_Lab_UW!
  • April 2019, Andreas Kyrvasilis was awarded the sophomore research scholarship. Congratulations!
  • April 2019, Kyle Brown's paper on a photocleavable surfactant for top-down proteomics is published in Nature Methods! [Article] [News Release]
  • April 2019, Bifan received the Gary Parr Memorial Award! Congratulations!
  • April 2019, Abe is awarded the Doban Mentoring Award! Congratulations!
  • April 2019, Morgan received the Eugene and Patricia Kreger Herscher Scholarship, the Henry and Eleanor Firminhac Chemistry Scholarship, and the Margaret McLean Bender Scholarship!
  • Feburary 2019, Trisha Tucholski is awarded the 2019 ASMS (American Society for Mass Spectrometry) Graduate Student Travel Award. Congratulations!
  • January 2019, The Ge Lab celebrated a Holiday Party! [Photos]

Most Recent Publications

  1. Melby, J.A.; Brown, K.A.; Gregorich, Z.R.; Roberts, D.S.; Chapman, E.A.; Ehlers, L.E.; Gao, Z.; Larson, E.J.; Jin, Y.; Lopez, J.; Hartung, J.; Zhu, Y.; Wang, D.; Guo, W.; Diffee, G.M.; Ge, Y.; High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms. bioRxiv, 2022. Article
  2. Wu, Q.; Bell, B.A.; Yan, J.; Chevrette, M.G.; Brittin, N.J.; Zhu, Y.; Chanana, S.; Maity, M.; Braun, D.R.; Wheaton, A.M.; Guzei, I.A.; Ge, Y.; Rajski, S.R.; Thomas, M.G.; Bugni, T.S.; SR Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora. J. Am. Chem. Soc., 2022, Online ahead of print. Article
  3.  Sun M.; Jin Y.; Zhang Y.; Gregorich Z.R.; Ren J.; Ge Y.; Guo W.; SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20. Genes, 2022, 13(9), 1526. Article.
  4.  Roberts, D.S.; Mann, M.; Li, B.H.; Kim, D.; Brasier, A.R.; Jin, S. Ge, Y. Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry. Chem. Sci. 2022, Epub ahead of print. Article.
  5.  Larson, E.J.; Gregorich, Z.R.; Zhang, Y.; Li, B.H.; Aballo, T.J.; Melby, J.A.; Ge, Y.; Guo, W. RBM20 Ablation is Associated With Changes in The Expression of Titin-Interacting and Metabolic Proteins. Molecular Omics, 2022. Article.
  6. Gupta, K.; Brown, K.A.; Hsieh, M.L.; Hoover, B.; Wang, J.; Khoury, M.K.; Pilli, V.S.S.; Beyer, R.S.; Voruganti, N.R.; Chaudhary, S.; Roberts, D.S.; Murphy, R.M.; Hong, S.; Ge, Y.; Liu, B. Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL. Journal of Extracellular Vesicles, 2022, 11, e12261. Article.
  7. Zhu, Y.; Esnault, S.; Ge, Y.; Jarjour, N.N; Brasier, A.R. Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling. Clin Proteomics. 2022, 19(1), 15. Article.
  8. Zhu, Y.; Esnault, S.; Ge, Y.; Jarjour, N.N.; Brasier, A.R. Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma. Metabolites, 2022, 12(5), 381. Article.
  9. Tiambeng, T.N.; Wu, Z.; Melby, J.A.; Ge, Y. Size Exclusion Chromatography Strategies and MASH Explorer for Large Proteoform Characterization. Methods Mol Biol. 2022, 2500, 15-30. Article.
  10. Zhang, Y.; Wang, C.; Sun, M.; Jin, Y.; Braz, C.U.; Khatib, H.; Hacker, T.A.; Liss, M.; Gotthardt, M.; Granzier, H.; Ge, Y.; Guo, W. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB Journal, 2022, Epub ahead of print. Article.
  11. Buck, K.M.; Roberts, D.S.; Aballo, T.J.; Inman, D.R.; Jin, S.; Ponik, S.; Brown, K.A.; Ge, Y. One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant. Anal. Chem., 2022, 94, 7164-7168. Article.
  12. Li, A.; Campbell, K.; Lal, S.; Ge, Y.; Keogh, A.; Macdonald, P.S.; Lau, P.; Linke, W.A.; Van der Velden, J.; Field, A.; Martinac, B.; Grosser, M.; dos Remedios, C. Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease Biophysical Reviews. 2022, 14, 369-379. Article.
  13. Smith, L.M.; Agar, J.N.; Chamot-Rooke, J.; Danis, P.O.; Ge, Y. ; Loo, J.A.; Pasa-Tolic, L.; Tsybin, Y.O.; Kelleher, N.L. The Human Proteoform Project: Defining the Human Proteome Science Adv., 2021, 7, 46. Article.
  14. Brown, K.A.; Anderson, C.; Reilly, L.; Sondhi, K.; Ge, Y.; Eckhardt, L.L. Proteomic Analysis of the Functional Inward Rectifier Potassium Channel (Kir) 2.1 Reveals Several Novel Phosphorylation Sites Biochemistry, 2021, Online ahead of print. Article.
  15. Bayne, E.B.; Simmons, A.D.; Roberts, D.S.; Zhu, Y.; Aballo, T.A.; Wancewicz, B.; Palecek, S.P.; Ge, Y. Multiomics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem-Cell Derived Cardiomyocytes J. Proteome Res., 2021, 20, 10, 4646-4654. Article.
  16. Truchan, N.A.; Fenske, R.J.; Sandhu, H.K.; Weeks, A.M.; Patibandla, C.; Wancewicz, B.; Pabich, S.' Reuter, A.; Reuter, A.; Harrington, J.M.; Brill, A.L.; Peter, D.C.; Nall, R.; Daniels, M.; Punt, M.; Kaiser, C.E.; Cox, E.D.; Ge, Y.; Davis, D.B.; Kimple, M.E. Human Islet Expression Levels of Prostaglandin E2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity ACS Pharmacol. Transl. Sci., 2021, 4, 4, 1338–1348. Article.
  17. Roberts, D.S.; Mann, M.; Melby, J.A.; Larson, E.J.; Zhu, Y.; Brasier, A.R.; Jin, S.; Ge, Y. Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry J. Am. Chem. Soc., 2021, 143, 31, 12014–12024. Article.
  18. Larson, E. J.; Roberts, D. S.; Melby, J. A.; Zhu, Y.; Buck, K. M.; Zhou, S.; Han, L.; Zhang, Q.; Ge, Y. High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry Anal. Chem., 2021, 93, 29, 10013–10021. Article.
  19. Aballo, T. J.; Roberts, D. S.; Melby, J. A.; Buck, K. M.; Brown, K. A; Ge, Y. Ultrafast and Reproducible Proteomics from Small Amounts of Heart Tissue Enabled by Azo and timsTOF Pro J. Proteome Res., 2021, 20, 8, 4203–4211. Article.
  20. Melby, J.A.; Roberts, D.S.; Larson, E.J.; Brown, K.A.; Bayne, E.B.; Jin, S.; Ge, Y. Novel Strategies to Address the Challenges in Top-Down Proteomics J. Am. Soc. Mass Spectrom., 2021, 32, 6, 1278–1294. Article.
  21. Kurgan, K.W.; Chen, B.; Brown, K.A.; Falco Cobra, P.; Ye, X.; Ge, Y.; Gellman; S.H. Stable Picodisc Assemblies from Saposin Proteins and Branched Detergents Biochemistry, 2021, 60 (14), 1108-1119. Article.
  22. Mann, M.; ; Roberts, D.S.; Zhu, Y.; Li, Y.; Zhou, J.; Brasier, A.R.; Ge, Y. Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry Viruses, 2021, 13 (3), 454. Article.
  23. Melby, J.A.; de Lange, W.J.; Zhang, J.; Roberts, D.S.; Mitchell, S.D.; Tucholski, T.; Kim, G.; Kyrvasilis, A.; McIlwain, S.J.; Kamp, T.J.; Ralphe, J.C.; Ge, Y. Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues J. Proteome Res., 2021, 20 (2), 1424-1433. Article.
  24. Schaid, M.D.; Zhu, Y.; Richardson, N.E.; Patibandla, C.; Ong, I.M.; Fenske, R.J.; Neuman, J.C.; Guthery, E.; Reuter, A.; Sandhu, H.K.; Fuller, M.H.; Cox, E.D.; Davis, D.B.; Layden, B.T.; Brasier, A.R., Lamming, D.W.; Ge, Y.; Kimple, M.E. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes Metabolites, 2021, 11(1), 58. Article.
  25. Brown, K.A.; Melby, J.A.; Roberts, D.S.; Ge, Y. Top-down Proteomics: Challenges, Innovations, and Applications in Basic and Clinical Research Expert Rev Proteomics, 2020, 1-15. Article.
  26. Knott, S.J.; Brown, K.A.; Josyer, H.; Carr, A.; Inman, D.;Friedl, A.; Ponik, S.M.; Ge, Y. Photocleavable Surfactant-Enabled Extracellular Matrix Proteomics Anal. Chem, 2020, 92 (24), 15693-15698. Article.
  27. Brown, K.A.; Tucholski, T.; Alpert, A.J.; Eken, C.; Wesemann, L.; Kyrvalis, A.; Jin, S.; Ge, Y. Top-Down Proteomics of Endogenous Membrane Proteins Enabled by Cloud Point Enrichment and Multidimensional Liquid Chromatography–Mass Spectrometry Anal. Chem, 2020, 92 (24), 15726-15735. Article.
  28. Styles, M.J.; Early, S.A.; Tucholski, T.; West, K.H.J.; Ge, Y.; Blackwell, H.E. Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor, ACS Infect. Dis., 2020, 6 (12), 3092-3103. Article.
  29. Larson, E.J.; Zhu, Y.; Wu, Z.; Chen, B.; Zhang, Z.; Zhou, S.; Han, L.; Zhang, Q.; Ge, Y.; Rapid Analysis of Reduced Antibody Drug Conjugate by Online LC-MS/MS with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal. Chem., 2020, 92, 22, 15096-15103. Article.
  30. Zhou, M.; Lantz, C.; Brown, K.A.; Ge, Y.; Pasa-Tolic, L.; Loo, J.A.; Lermyte, F.; Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry, Chem. Science, 2020, 11, 12918-12936.Article.
  31. Zhu, Y.; Wancewicz, B.; Schaid, M.; Tiambeng, T.N.; Wenger, K.; Jin, Y.; Heyman, H.; Thompson, C.J.; Barsch, A.; Cox, E.D.; Davis, D.B.; Brasier, A.R.; Kimple, M.; Ge, Y. Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research, J. Proteome Res., 2020, 20 (1), 463-473. Article.
  32. Tucholski, T.; Cai, W.; Gregorich, Z.R.; Bayne, E.F.; Mitchell, S.D.; McIlwain, S.J.; de Lange, W.J.; Wrobbel, M.; Karp, H.; Hite, Z.; Vikhorev, P.G.; Marston, S.B.; Lal, S.; Li, A.; dos Remedios, C.; Kohmoto, T.; Hermsen, J.; Ralphe, J.C.; Kamp, T.J.; Moss, R.L.; Ge, Y. Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics, Proc Natl Acad Sci USA, 2020, 117 (40), 24691-24700.Article.
  33. Kellie, J.F.; Tran, J.C.; Jian, W.; Jones, B.; Mehl, J.T.; Ge, Y.; Henion, J.; Bateman, K.P. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective, J. Am. Soc. Mass Spectrom., 2020, Online ahead of print. Article.
  34. Tucholski, T.; Ge, Y. Fourier‐transform ion cyclotron resonance mass spectrometry for characterizing proteoforms, Mass Spectrom. Rev., 2020, Online ahead of print. Article.
  35. Tiambeng, T. N.*; Roberts, D.S.*; Brown, K.A.; Zhu, Y.; Chen, B.; Wu, Z.; Mitchell, S.D.; Guardado-Alvarez, T.M.; Jin, Y.; Ge, Y. Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum., Nat Commun., 2020, 11 (1), 1-12. Article.
  36. Wu, Z.; Roberts, D.S.; Melby, J.A.; Wenger, K.; Wetzel, M.; Gu, Y.; Ramanathan, S.G.; Bayne, E.F.; Liu, X.; Sun, R.; Ong, I.M.; McIlwain, S.J.; Ge, Y. MASH Explorer: A Universal Software Environment for Top-Down Proteomics., J. Proteome Res., 2020, 19, 9, 3867–3876. Article.
  37. Srzentic, K.; Fornelli, L.; Tsybin, Y.O.; Loo, J.A.; Seckler, H.; Agar, J.N.; Anderson, L.C.; Bai, D.L.; Beck, A.; Brodbelt, J.S.; van der Burgt, Y.E.M.; Chamot-Rooke, J.; Chatterjee, S.; Chen, Y.; Clarke, D.J.; Danis, P.O.; Diedrich, J.K.; D'Ippolito, R.A.; Dupré, M.; Gasilova, N.; Ge, Y.; Ah Goo, Y.; Goodlett, D.R.; Greer, S.M.; Haselmann, K.F.; He, L.; Hendrickson, C.L.; Hinkle, J.D.; Holt, M.; Hughes, S.; Hunt, D.F.; Kelleher, N.L.; Kozhinov, A.N.; Lin, Z.; Malosse, C.; Marshall, A.G.; Menin, L.; Millikin, R.J.; Nagornov, K.O.; Nicolardi, S.; Paša-Tolić, L.; Pengelley, S.; Quebbemann, N.R.; Resemann, A.; Sandoval, W.; Sarin, R.; Schmitt, N.D.; Shabanowitz, J.; Shaw, J.B.; Shortreed, M.R.; Smith, L.M.; Sobott, F.; Suckau, D.; Toby, T.; Weisbrod, C.R.; Wildburger, N.C.; Yates, J.R.; Yoon, S.H.; Young, N.L.; Zhou, M. Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2020, 31, 9, 1783–1802. Article.
  38. Xu, B.; Li, M.; Wang, Y.; Zhao, M.; Morotti, S.; Shi, Q.; Wang, Q.; Barbagallo, F.; Teoh, J.; Reddy, G.R.; Bayne, E.F.; Liu, Y.; Shen, A.; Puglisi, J.L. Ge, Y.; Li, J.; Grandi, E.; Nieves-Cintron, M.; Xiang, Y.K. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failureβ, Circ Res., 2020, 127, 796–810. Article.
  39. McIlwain, S.; Wu, Z.; Wetzel, M.; Belongia, D.; Jin, Y.; Wenger, K.; Ong, I.; Ge, Y. Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy., J. Am. Soc. Mass Spectrom., 2020, 31(5), 1104-1113. Article.
  40. Brown, K; Tucholski, T; Eken, C; Knott, S; Zhu, Y; Jin, S; Ge, Y. High-throughput Proteomics Enabled by a Photocleavable Surfactant., Angew Chem Int Ed Engl., 2020, 59(22), 8406-8410. Article.
  41. Zhang, F; Wyche, TP; Zhu, Y; Braun, DR; Yan, JX; Chanana, S; Ge, Y.; Guzei, IA; Chevrette, MG; Currie, CR; Thomas, MG; Rajski, SR; Bugni, TS.; MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product., Org Lett., 2020, 22(4), 1275-1279. Article.
  42. Melby, J. A.; Jin, Y.; Lin, Z.; Tucholski, T.; Wu, Z.; Gregorich, Z. R.; Diffee, G. M.; Ge, Y. Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues., J. Proteome Res., 2020,19(1), 443–454. (Article selected for cover of Jan. issue) Article.
  43. Bortnov, V.; Tonelli, M.; Lee, W.; Lin, Z.; Annis, D. S.; Demerdash, O.; Bateman, A.; Mitchell, J.; Ge, Y.; Markley, J. L.; Mosher, D. F. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum, Nature Commun., 2019, 10, 1-14. Article.
  44. Cai, W.; Zhang, J.; De Lange, W. J.; Gregorich, Z. R.; Karp, H.; Ferrell, E. T.; Mitchell, S. T.; Tucholski, T.; Lin, Z.; Biermann, M.; McIlwain, S.; Ralphe, J. C.; Kamp, T. J.; Ge, Y. Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes., Circ Res., 2019, 125, 936–953. Article.
  45. Tiambeng, T. N.; Tucholski, T.; Wu, Z.; Zhu, Y.; Mitchell, S. D.; Roberts, D. S.; Jin, Y.; Ge, Y. Analysis of cardiac troponin proteoforms by top-down mass spectrometry, Methods Enzymol., ISSN 0076-6879 Article.
  46. Wu, Z.; Jin, Y.; Chen, B.; Gugger, M. K.; Wilkinson-Johnson, C. L.; Tiambeng, T. N.; Jin, S.; Ge, Y., Comprehensive Characterization of Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2019, 30, 2561-2570. Article.
  47. Smith, L. M.; Thomas, P. M.; Shortreed, M. R.; Scheffer, L. V.; Fellers, R. T.; LuDec, R. D.; Tucholski, T.; Ge, Y.; Agar, J. N.; Anderson, L. C.; Chamot-Rooke, J.; Gault, J.; Loo, J. A.; Pasa-Tolic, L.; Robinson, C. V.; Schluter, H.; Tsybin, Y. O.; Vilaseca, M.; Vizcaino, J. A.; Danis, P. O.; Kelleher, N. L., A five-level classification system for proteoform identifications, Nature Methods. 2019, 16, 939-940. Article.
  48. Chen, B.; Lin, Z.; Zhu, Y.; Jin, Y.; Larson, E.; Xu, Q.; Fu, C.; Zhang, Z.; Zhang, Q.; Pritts, W. A.; Ge, Y. Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation., Anal Chem. 2019, 16, 18, 11661-11669. Article.
  49. Schaffer, L. A.; Tucholski, T.; Shortreed, M. R.; Ge, Y.; Smith, L. M., Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms., Anal Chem. 2019, 19, 10937-10942. Article.
  50. Biermann, M.; Cai, W.; Lang, D.; Hermsen, J.; Profio, L.; Zhou, Y.; Czirok, A.; Isai, D. G.; Napiwocki, B. N.; Rodriguez, A. M.; Brown, M. E.; Woon, M. T.; Shao, A.; Han, T.; Park, D.; Hacker, T. A.; Crone, W. C.; Burlingham, W. J.; Glukhov, A. V.; Ge, Y.; Kamp, T. J., Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation, Stem Cells. 2019, 37, 910-923. Article.
  51. Brown, K. A.; Chen, B.; Guardado-Alvarez, T. M.; Lin, Z.; Hwang, L.; Ayaz-Guner, S.; Jin, S.; Ge, Y. A Photocleavable Surfactant for Top-Down Proteomics, Nature Methods. 2019, 16, 417-420. News Release.
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  54. Roberts, D. S.; Chen, B.; Tiambeng, T. N.; Wu, Z.; Ge, Y.; Jin, S. Reproducible large-scale synthesis of surface silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the human heart phosphoproteome, Nano Res., 2019, 12, 1473-1481. DOI: 10.1007/s12274-019-2418-4. Article.
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  58. Gregorich, Z.R.; Patel, J.R.; Cai, W.; Lin, Z.; Heurer, R.; Fitzsimons, D.P.; Moss, R.L.; Ge, Y. Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium, J Gen Physiol., 2019. PII: jgp.201812214. DOI: 10.1085/jgp.201812214. Article

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