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152. Zhang, Y.; Wang, C.; Sun, M.; Jin, Y.; Braz, C.U.; Khatib, H.; Hacker, T.A.; Liss, M.; Gotthardt, M.; Granzier, H.; Ge, Y.; Guo, W. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis FASEB Journal, 2022, Online ahead of print. Article.
151. Buck, K.M.; Roberts, D.S.; Aballo, T.J.; Inman, D.R.; Jin, S.; Ponik, S.; Brown, K.A.; Ge, Y. One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant BioRxiv, 2022. Article.
150. Roberts, D.S.; Mann, M.; Li, B.H.; Kim, D.; Brasier, A.R.; Jin, S. Ge, Y. Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry BioRxiv, 2022. Article.
149. Li, A.; Campbell, K.; Lal, S.; Ge, Y.; Keogh, A.; Macdonald, P.S.; Lau, P.; Linke, W.A.; Van der Velden, J.; Field, A.; Martinac, B.; Grosser, M.; dos Remedios, C. Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease Biophysical Reviews , 2022, 1-11. Article.
148. Smith, L.M.; Agar, J.N.; Chamot-Rooke, J.; Danis, P.O.; Ge, Y. ; Loo, J.A.; Pasa-Tolic, L.; Tsybin, Y.O.; Kelleher, N.L. The Human Proteoform Project: Defining the Human Proteome Science Adv., 2021, 7, 46. Article.
147. Brown, K.A.; Anderson, C.; Reilly, L.; Sondhi, K.; Ge, Y.; Eckhardt, L.L. Proteomic Analysis of the Functional Inward Rectifier Potassium Channel (Kir) 2.1 Reveals Several Novel Phosphorylation Sites Biochemistry, 2021, Online ahead of print. Article.
146. Bayne, E.B.; Simmons, A.D.; Roberts, D.S.; Zhu, Y.; Aballo, T.A.; Wancewicz, B.; Palecek, S.P.; Ge, Y. Multiomics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem-Cell Derived Cardiomyocytes J. Proteome Res., 2021, 20, 10, 4646-4654. Article.
145. Truchan, N.A.; Fenske, R.J.; Sandhu, H.K.; Weeks, A.M.; Patibandla, C.; Wancewicz, B.; Pabich, S.' Reuter, A.; Reuter, A.; Harrington, J.M.; Brill, A.L.; Peter, D.C.; Nall, R.; Daniels, M.; Punt, M.; Kaiser, C.E.; Cox, E.D.; Ge, Y.; Davis, D.B.; Kimple, M.E. Human Islet Expression Levels of Prostaglandin E2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity ACS Pharmacol. Transl. Sci., 2021, 4, 4, 1338–1348. Article.
144. Roberts, D.S.; Mann, M.; Melby, J.A.; Larson, E.J.; Zhu, Y.; Brasier, A.R.; Jin, S.; Ge, Y. Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry J. Am. Chem. Soc., 2021, 143, 31, 12014–12024. Article.
143. Larson, E. J.; Roberts, D. S.; Melby, J. A.; Zhu, Y.; Buck, K. M.; Zhou, S.; Han, L.; Zhang, Q.; Ge, Y. High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry Anal. Chem., 2021, 93, 29, 10013–10021. Article.
142. Aballo, T. J.; Roberts, D. S.; Melby, J. A.; Buck, K. M.; Brown, K. A; Ge, Y. Ultrafast and Reproducible Proteomics from Small Amounts of Heart Tissue Enabled by Azo and timsTOF Pro J. Proteome Res., 2021, 20, 8, 4203–4211. Article.
141. Melby, J.A.; Roberts, D.S.; Larson, E.J.; Brown, K.A.; Bayne, E.B.; Jin, S.; Ge, Y. Novel Strategies to Address the Challenges in Top-Down Proteomics J. Am. Soc. Mass Spectrom., 2021, 32, 6, 1278–1294. Article.
140. Kurgan, K.W.; Chen, B.; Brown, K.A.; Falco Cobra, P.; Ye, X.; Ge, Y.; Gellman; S.H. Stable Picodisc Assemblies from Saposin Proteins and Branched Detergents Biochemistry, 2021, 60 (14), 1108-1119. Article.
139. Mann, M.; ; Roberts, D.S.; Zhu, Y.; Li, Y.; Zhou, J.; Brasier, A.R.; Ge, Y. Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry Viruses, 2021, 13 (3), 454. Article.
138. Melby, J.A.; de Lange, W.J.; Zhang, J.; Roberts, D.S.; Mitchell, S.D.; Tucholski, T.; Kim, G.; Kyrvasilis, A.; McIlwain, S.J.; Kamp, T.J.; Ralphe, J.C.; Ge, Y. Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues J. Proteome Res., 2021, 20 (2), 1424-1433. Article.
137. Schaid, M.D.; Zhu, Y.; Richardson, N.E.; Patibandla, C.; Ong, I.M.; Fenske, R.J.; Neuman, J.C.; Guthery, E.; Reuter, A.; Sandhu, H.K.; Fuller, M.H.; Cox, E.D.; Davis, D.B.; Layden, B.T.; Brasier, A.R., Lamming, D.W.; Ge, Y.; Kimple, M.E. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes Metabolites, 2021, 11(1), 58. Article.
136. Brown, K.A.; Melby, J.A.; Roberts, D.S.; Ge, Y. Top-down Proteomics: Challenges, Innovations, and Applications in Basic and Clinical Research Expert Rev Proteomics, 2020, 1-15. Article.
135. Knott, S.J.; Brown, K.A.; Josyer, H.; Carr, A.; Inman, D.;Friedl, A.; Ponik, S.M.; Ge, Y. Photocleavable Surfactant-Enabled Extracellular Matrix Proteomics Anal. Chem, 2020, 92 (24), 15693-15698. Article.
134. Brown, K.A.; Tucholski, T.; Alpert, A.J.; Eken, C.; Wesemann, L.; Kyrvalis, A.; Jin, S.; Ge, Y. Top-Down Proteomics of Endogenous Membrane Proteins Enabled by Cloud Point Enrichment and Multidimensional Liquid Chromatography–Mass Spectrometry Anal. Chem, 2020, 92 (24), 15726-15735. Article.
133. Styles, M.J.; Early, S.A.; Tucholski, T.; West, K.H.J.; Ge, Y.; Blackwell, H.E. Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor, ACS Infect. Dis., 2020, 6 (12), 3092-3103. Article.
132. Larson, E.J.; Zhu, Y.; Wu, Z.; Chen, B.; Zhang, Z.; Zhou, S.; Han, L.; Zhang, Q.; Ge, Y.; Rapid Analysis of Reduced Antibody Drug Conjugate by Online LC-MS/MS with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal. Chem., 2020, 92, 22, 15096-15103. Article.
131. Zhou, M.; Lantz, C.; Brown, K.A.; Ge, Y.; Pasa-Tolic, L.; Loo, J.A.; Lermyte, F.; Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry, Chem. Science, 2020, 11, 12918-12936.Article.
130. Zhu, Y.; Wancewicz, B.; Schaid, M.; Tiambeng, T.N.; Wenger, K.; Jin, Y.; Heyman, H.; Thompson, C.J.; Barsch, A.; Cox, E.D.; Davis, D.B.; Brasier, A.R.; Kimple, M.; Ge, Y. Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research, J. Proteome Res., 2020, 20 (1), 463-473. Article.
129. Tucholski, T.; Cai, W.; Gregorich, Z.R.; Bayne, E.F.; Mitchell, S.D.; McIlwain, S.J.; de Lange, W.J.; Wrobbel, M.; Karp, H.; Hite, Z.; Vikhorev, P.G.; Marston, S.B.; Lal, S.; Li, A.; dos Remedios, C.; Kohmoto, T.; Hermsen, J.; Ralphe, J.C.; Kamp, T.J.; Moss, R.L.; Ge, Y. Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics, Proc Natl Acad Sci USA, 2020, 117 (40), 24691-24700.Article.
128. Kellie, J.F.; Tran, J.C.; Jian, W.; Jones, B.; Mehl, J.T.; Ge, Y.; Henion, J.; Bateman, K.P. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective, J. Am. Soc. Mass Spectrom., 2020, Online ahead of print. Article.
127. Tucholski, T.; Ge, Y. Fourier‐transform ion cyclotron resonance mass spectrometry for characterizing proteoforms, Mass Spectrom. Rev., 2020, Online ahead of print. Article.
126. Tiambeng, T. N.*; Roberts, D.S.*; Brown, K.A.; Zhu, Y.; Chen, B.; Wu, Z.; Mitchell, S.D.; Guardado-Alvarez, T.M.; Jin, Y.; Ge, Y. Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum., Nat Commun., 2020, 11 (1), 1-12. Article.
125. Wu, Z.; Roberts, D.S.; Melby, J.A.; Wenger, K.; Wetzel, M.; Gu, Y.; Ramanathan, S.G.; Bayne, E.F.; Liu, X.; Sun, R.; Ong, I.M.; McIlwain, S.J.; Ge, Y. MASH Explorer: A Universal Software Environment for Top-Down Proteomics., J. Proteome Res., 2020, 19, 9, 3867–3876. Article.
124. Srzentic, K.; Fornelli, L.; Tsybin, Y.O.; Loo, J.A.; Seckler, H.; Agar, J.N.; Anderson, L.C.; Bai, D.L.; Beck, A.; Brodbelt, J.S.; van der Burgt, Y.E.M.; Chamot-Rooke, J.; Chatterjee, S.; Chen, Y.; Clarke, D.J.; Danis, P.O.; Diedrich, J.K.; D'Ippolito, R.A.; Dupré, M.; Gasilova, N.; Ge, Y.; Ah Goo, Y.; Goodlett, D.R.; Greer, S.M.; Haselmann, K.F.; He, L.; Hendrickson, C.L.; Hinkle, J.D.; Holt, M.; Hughes, S.; Hunt, D.F.; Kelleher, N.L.; Kozhinov, A.N.; Lin, Z.; Malosse, C.; Marshall, A.G.; Menin, L.; Millikin, R.J.; Nagornov, K.O.; Nicolardi, S.; Paša-Tolić, L.; Pengelley, S.; Quebbemann, N.R.; Resemann, A.; Sandoval, W.; Sarin, R.; Schmitt, N.D.; Shabanowitz, J.; Shaw, J.B.; Shortreed, M.R.; Smith, L.M.; Sobott, F.; Suckau, D.; Toby, T.; Weisbrod, C.R.; Wildburger, N.C.; Yates, J.R.; Yoon, S.H.; Young, N.L.; Zhou, M. Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2020, 31, 9, 1783–1802. Article.
123. Xu, B.; Li, M.; Wang, Y.; Zhao, M.; Morotti, S.; Shi, Q.; Wang, Q.; Barbagallo, F.; Teoh, J.; Reddy, G.R.; Bayne, E.F.; Liu, Y.; Shen, A.; Puglisi, J.L. Ge, Y.; Li, J.; Grandi, E.; Nieves-Cintron, M.; Xiang, Y.K. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failureβ, Circ Res., 2020, 127, 796–810. Article.
122. McIlwain, S.; Wu, Z.; Wetzel, M.; Belongia, D.; Jin, Y.; Wenger, K.; Ong, I.; Ge, Y. Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy., J. Am. Soc. Mass Spectrom., 2020, 31(5), 1104-1113. Article.
121. Brown, K; Tucholski, T; Eken, C; Knott, S; Zhu, Y; Jin, S; Ge, Y. High-throughput Proteomics Enabled by a Photocleavable Surfactant., Angew Chem Int Ed Engl., 2020, 59(22), 8406-8410. Article.
120. Zhang, F; Wyche, TP; Zhu, Y; Braun, DR; Yan, JX; Chanana, S; Ge, Y.; Guzei, IA; Chevrette, MG; Currie, CR; Thomas, MG; Rajski, SR; Bugni, TS.; MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product., Org Lett., 2020, 22(4), 1275-1279. Article.
119. Melby, J. A.; Jin, Y.; Lin, Z.; Tucholski, T.; Wu, Z.; Gregorich, Z. R.; Diffee, G. M.; Ge, Y. Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues., J. Proteome Res., 2020,19(1), 443–454. (Article selected for cover of Jan. issue) Article.
118. Bortnov, V.; Tonelli, M.; Lee, W.; Lin, Z.; Annis, D. S.; Demerdash, O.; Bateman, A.; Mitchell, J.; Ge, Y.; Markley, J. L.; Mosher, D. F. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum, Nature Commun., 2019, 10, 1-14. Article.
117. Cai, W.; Zhang, J.; De Lange, W. J.; Gregorich, Z. R.; Karp, H.; Ferrell, E. T.; Mitchell, S. T.; Tucholski, T.; Lin, Z.; Biermann, M.; McIlwain, S.; Ralphe, J. C.; Kamp, T. J.; Ge, Y. Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes., Circ Res., 2019, 125, 936–953. Article.
116. Tiambeng, T. N.; Tucholski, T.; Wu, Z.; Zhu, Y.; Mitchell, S. D.; Roberts, D. S.; Jin, Y.; Ge, Y. Analysis of cardiac troponin proteoforms by top-down mass spectrometry, Methods Enzymol., ISSN 0076-6879 Article.
115. Wu, Z.; Jin, Y.; Chen, B.; Gugger, M. K.; Wilkinson-Johnson, C. L.; Tiambeng, T. N.; Jin, S.; Ge, Y., Comprehensive Characterization of Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2019, 30, 2561-2570. Article.
114. Smith, L. M.; Thomas, P. M.; Shortreed, M. R.; Scheffer, L. V.; Fellers, R. T.; LuDec, R. D.; Tucholski, T.; Ge, Y.; Agar, J. N.; Anderson, L. C.; Chamot-Rooke, J.; Gault, J.; Loo, J. A.; Pasa-Tolic, L.; Robinson, C. V.; Schluter, H.; Tsybin, Y. O.; Vilaseca, M.; Vizcaino, J. A.; Danis, P. O.; Kelleher, N. L., A five-level classification system for proteoform identifications, Nature Methods. 2019, 16, 939-940. Article.
113. Chen, B.; Lin, Z.; Zhu, Y.; Jin, Y.; Larson, E.; Xu, Q.; Fu, C.; Zhang, Z.; Zhang, Q.; Pritts, W. A.; Ge, Y. Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation., Anal Chem. 2019, 16, 18, 11661-11669. Article.
112. Schaffer, L. A.; Tucholski, T.; Shortreed, M. R.; Ge, Y.; Smith, L. M., Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms., Anal Chem. 2019, 19, 10937-10942. Article.
111. Biermann, M.; Cai, W.; Lang, D.; Hermsen, J.; Profio, L.; Zhou, Y.; Czirok, A.; Isai, D. G.; Napiwocki, B. N.; Rodriguez, A. M.; Brown, M. E.; Woon, M. T.; Shao, A.; Han, T.; Park, D.; Hacker, T. A.; Crone, W. C.; Burlingham, W. J.; Glukhov, A. V.; Ge, Y.; Kamp, T. J., Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation, Stem Cells. 2019, 37, 910-923. Article.
110. Brown, K. A.; Chen, B.; Guardado-Alvarez, T. M.; Lin, Z.; Hwang, L.; Ayaz-Guner, S.; Jin, S.; Ge, Y. A Photocleavable Surfactant for Top-Down Proteomics, Nature Methods. 2019, 16, 417-420. News Release.
109. Donnelly, D. P.; Rawlins, C. M.; DeHart, C. J.; Fornelli,, L.; Schachner, L. F.; Lin, Z.; Lippens, J. L.; Aluri, K. C.; Sarin, R.; Chen, B.; Lantz, C.; Jung, W.; Johnson, K. R.; Koller, A.; Wolff, J. J.; Campuzano, I. D. G.; Auclair, J. R.; Ivanov, A. R.; Whitelegge, J. P.; Paša-Tolić, L.; Chamot-Rooke, J.; Danis, P. O.; Smith, L. M.; Tsybin, Y. O.; Loo, J. A.; Ge Y.; Kelleher N. L.; Agar J. N. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry., Nature Methods. 2019, 16, 587-594. Article.
108. Schaffer, L. V.; Millikin, R. J.; Miller, R. M.; Anderson, L. C.; Fellers R. T.; Ge Y.; Kelleher N. L.; LeDuc R. D.; Liu X.; Payne, S. H.; Sun, L.; Thomas, P. M.; Tucholski, T.; Wang, Z.; Wu, S.; Wu, Z.; Yu, D.; Shortreed, M. R.; Smith, L. M. Identification and Quantification of Proteoforms by Mass Spectrometry, Proteomics, 2019, 19, 1800361 Article.
107. Roberts, D. S.; Chen, B.; Tiambeng, T. N.; Wu, Z.; Ge, Y.; Jin, S. Reproducible large-scale synthesis of surface silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the human heart phosphoproteome, Nano Res., 2019, 12, 1473-1481. DOI: 10.1007/s12274-019-2418-4. Article.
106. Jin, Y.; Diffee, G. M.; Colman, R. J.; Anderson, R. M.; Ge, Y. Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle, J. Am. Soc. Mass Spectrom. 2019. Epub ahead of print. DOI: 10.1007/s13361-019-02139-0 Article
105. Tucholski, T.; Knott, S.; Chen, B.; Pistono, P.; Lin, Z.; Ge, Y. A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal Chem., 2019, 91, 3855-3844. DOI: 10.1021/acs.analchem.8b04082. Article
104. Liang, Y.; Jin, Y.; Wu, Z.; Tucholski, T.; Brown, K.A.; Zhang, L.; Zhang, Y.; Ge, Y. Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-down Proteomics, Anal Chem., 2019, 91, 3, 1743-1747. DOI: 10.1021/acs.analchem.8b05817. Article
103. Gregorich, Z.R.; Patel, J.R.; Cai, W.; Lin, Z.; Heurer, R.; Fitzsimons, D.P.; Moss, R.L.; Ge, Y. Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium, J Gen Physiol., 2019. PII: jgp.201812214. DOI: 10.1085/jgp.201812214. Article

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