Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.

Read more...


Ying Ge, PhD

Professor, Department of Cell and Regenerative Biology
Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology


Follow Us On Twitter!

    News and Updates

  • May 2023, Jake’s high sensitivity paper on single muscle cell heterogeneity in large proteoforms was published in PNAS! [Link]
  • May 2023, David S. Roberts successfully defended his thesis and is moving on to post-doc at Stanford. May the force be with you!
  • April 2023, Jake Melby successfully defended his thesis and is moving on to a position at AstraZeneca. We wish you all the best!
  • March 2023, Congratulations to ELI J LARSON on winning the Chemistry Department Gary Parr Award!
  • March 2023, Congratulations to DAVID S ROBERTS on winning the Chemistry Department Ivanisevic award!
  • March 2023, Elizabeth Bayne won an ASMS Graduate Student Travel Award. Congratulations!
  • December 2022, Congratulations to our fearless leader, Ying Ge, for winning a HUPO award in Clinical and Translational Proteomics!
  • December 2022, Anna Grace Towler, Mallory Wilson, Matthew Fischer, Ruby Chan, and Yareslie Rivera joined our lab from the Chemistry program! Welcome to the Ge Group!
  • November 2022, Elizabeth Bayne won Best Lightening Talk and Kalina Reese won Best Poster Award at the 2nd CASMS (Chinese American Society for Mass Spectrometry) Virtual Conference. Congratulations!
  • October 2022, Elizabeth Bayne won Second Place Poster Prize at the UW-Madison Cardiovascular Research Summit!
  • September 2022, Congratulations to David Roberts for winning the graduate student Travel Award to attend the 21st World Congress of the Human Proteome Organization (HUPO 2022)!
  • June 2022, Congratulations to Eli Larson for winning the graduate student travel award for the HPLC conference!
  • April 2022, Congratulations to Bridget Knight for receiving the Eugene and Patricia Kreger Herscher Scholarship! Well done!
  • April 2022, Congratulations to Kylie Plouff for winning the Honors Summer Apprentice award! Well done!
  • March 2022, Congrats to Brad Li for receiving the Biochemistry Undergraduate Summer Research Award!
  • February 2022, Melissa Pergande is awarded the 2022 American Society for Mass Spectrometry (ASMS) Postdoc Career Development Award. Congratulations! [Link]
  • February 2022, Jake Melby is awarded the 2022 American Society for Mass Spectrometry (ASMS) Graduate Student Travel Award. Congratulations
  • February 2022, Jake Melby is awarded the 2022 Gary Parr Memorial Award from the Department of Chemistry. Congratulations!
  • February 2022, Congratulations to Elizabeth Bayne for winning the 2022 Clinical and Pharmaceutical Solutions through Analysis Steven A. Hofstadler Student Award!
  • January 2022, Jake Melby won the 2022 Chinese American Chromatography Association (CACA) Student Excellence Award. Congratulations! [Link]
         More

Most Recent Publications

  1. Melby, J.A.; Brown, K.A.; Gregorich, Z.R.; Roberts, D.S.; Chapman, E.A.; Ehlers, L.E.; Gao, Z.; Larson, E.J.; Jin, Y.; Lopez, J.R.; Hartung, J.; Zhu, Y.; McIlwain, S.J.; Wang, D.; Guo, W.; Diffee, G.M.; Ge, Y. High sensitivity top–down proteomics captures single muscle cell heterogeneity in large proteoforms. PNAS. 2023, 120(19), e2222081120. Article
  2. Rossler, K.J.; de Lange, W.; Mann, M.W.; Aballo, T.J.; Melby, J.A.; Zhang, J.; Kim, G.; Bayne, E.F.; Zhu, Y.; Farrell, E.T.; Kamp, T.J.; Ralphe, J.C.; Ge, Y. Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs. bioRxiv. 2023. Article
  3. Rogers, H.T.; Roberts, D.S.; Larson, E.J.; Melby, J.A.; Rossler, K.J.; Carr, A.V.; Brown, K.A.; Ge, Y. Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics. bioRxiv. 2023.
  4. Wancewicz, B.; Zhu, Y.; Fenske, R.K.; Weeks, A.M.; Wenger, K.; Pabich, S.; Daniels, M.; Punt, M.; Nall, R.; Peter, D.C.; Brasier, A.; Cox, E.D.; Davis, D.B.; Ge, Y.; Kimple, M. Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort. J. of Pharmacology and Exp. Therapeutics. 2023. Article
  5. Aballo, T. J.; Roberts, D.S.; Bayne, E. F.; Zhu, W.; Walcott, G.; Mahmoud, A. I.; Zhang, J.; Ge, Y. Integrated Proteomics Reveals Alterations in Sarcomere Composition and Developmental Processes during Postnatal Swine Heart Development, J. Mol. Cell. Cardiol. 2023, 176, 33-40 Article
  6. Larson, E.J. ; Pergande, M. R; Moss, M. E.; Rossler, K. J.; Wenger, R. K.; Krichel, B.; Josyer, H.; Melby, J. A.; Roberts, D. S.; Pike, K.; Shi, Z.; Chan, H.; Knight, B.; Rogers, H. T.; Brown, K. A.; Ong, I. M.; Kyowon Jeong, K.; Marty, M.; McIlwain, S. J.; Ge, Y. MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing bioRxiv 2023, doi: 10.1101/2023.01.02.522513 Article
  7. Mann, M.; Fu, Y.; Xu, X.; Roberts, D.S.; Li, Y.; Zhou, J., Ge, Y.; Brasier, A.R. Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing. bioRxiv. 2023, DOI: 10.1101/2023.01.17.524257 Article
  8. Chapman, E.; Aballo, J. J.; Melby, J.A.; Zhou, T.; Price, S. J.; Rossler, K. J.; Lei, I.; Tang, P. C.; Ge, Y. Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-down Proteomics, J. Proteome Res. 2023, 22, 931–941 Article
  9. Bayne, E.F.; Rossler, K. J.; Gregorich, Z. R.; Aballo, T. J.; Roberts, D.S.; Chapman, E. A.;Guo, W.; Ralphe, J.C.; Kamp, T.J.; Ge, Y. Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart, bioRxiv, 2022. doi: 10.1101/2023.01.26.525767 Article
  10. Brown, K. A.; Gugger, M. K.; Roberts, D. S.; Moreno, M.; Chae, P. S.; Ge, Y.; Jin, S. Synthesis, Self-Assembly Properties, and Degradation Characterization of a Nonionic Photocleavable Azo-Sulfide Surfactant Family, Langmuir, 2023, DOI: 10.1021/acs.langmuir.2c02820 Article
  11. Wu, Q.; Bell, B.A.; Yan, J.; Chevrette, M.G.; Brittin, N.J.; Zhu, Y.; Chanana, S.; Maity, M.; Braun, D.R.; Wheaton, A.M.; Guzei, I.A.; Ge, Y.; Rajski, S.R.; Thomas, M.G.; Bugni, T.S.; SR Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora. J. Am. Chem. Soc. 2023, 145, 58–69. Article
  12. Brown, K.A.; Gugger, M.; Yu, Z.; Moreno, D.; Jin, S.; Ge, Y. A Nonionic, Cleavable Surfactant for Native Mass Spectrometry and Top-down Proteomics, Anal. Chem. 2023, 95, 1801–1804 Article
  13. Wu, Q.; Bell, B.A.; Yan, J.; Chevrette, M.G.; Brittin, N.J.; Zhu, Y.; Chanana, S.; Maity, M.; Braun, D.R.; Wheaton, A.M.; Guzei, I.A.; Ge, Y.; Rajski, S.R.; Thomas, M.G.; Bugni, T.S.; SR Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora. J. Am. Chem. Soc., 2022, Online ahead of print. Article
  14.  Sun M.; Jin Y.; Zhang Y.; Gregorich Z.R.; Ren J.; Ge Y.; Guo W.; SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20. Genes, 2022, 13(9), 1526. Article.
  15.  Roberts, D.S.; Mann, M.; Li, B.H.; Kim, D.; Brasier, A.R.; Jin, S. Ge, Y. Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry. Chem. Sci. 2022, Epub ahead of print. Article.
  16.  Larson, E.J.; Gregorich, Z.R.; Zhang, Y.; Li, B.H.; Aballo, T.J.; Melby, J.A.; Ge, Y.; Guo, W. RBM20 Ablation is Associated With Changes in The Expression of Titin-Interacting and Metabolic Proteins. Molecular Omics, 2022. Article.
  17. Gupta, K.; Brown, K.A.; Hsieh, M.L.; Hoover, B.; Wang, J.; Khoury, M.K.; Pilli, V.S.S.; Beyer, R.S.; Voruganti, N.R.; Chaudhary, S.; Roberts, D.S.; Murphy, R.M.; Hong, S.; Ge, Y.; Liu, B. Necroptosis is associated with Rab27-independent expulsion of extracellular vesicles containing RIPK3 and MLKL. Journal of Extracellular Vesicles, 2022, 11, e12261. Article.
  18. Zhu, Y.; Esnault, S.; Ge, Y.; Jarjour, N.N; Brasier, A.R. Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling. Clin Proteomics. 2022, 19(1), 15. Article.
  19. Zhu, Y.; Esnault, S.; Ge, Y.; Jarjour, N.N.; Brasier, A.R. Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma. Metabolites, 2022, 12(5), 381. Article.
  20. Tiambeng, T.N.; Wu, Z.; Melby, J.A.; Ge, Y. Size Exclusion Chromatography Strategies and MASH Explorer for Large Proteoform Characterization. Methods Mol Biol. 2022, 2500, 15-30. Article.
  21. Zhang, Y.; Wang, C.; Sun, M.; Jin, Y.; Braz, C.U.; Khatib, H.; Hacker, T.A.; Liss, M.; Gotthardt, M.; Granzier, H.; Ge, Y.; Guo, W. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB Journal, 2022, Epub ahead of print. Article.
  22. Buck, K.M.; Roberts, D.S.; Aballo, T.J.; Inman, D.R.; Jin, S.; Ponik, S.; Brown, K.A.; Ge, Y. One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant. Anal. Chem., 2022, 94, 7164-7168. Article.
  23. Li, A.; Campbell, K.; Lal, S.; Ge, Y.; Keogh, A.; Macdonald, P.S.; Lau, P.; Linke, W.A.; Van der Velden, J.; Field, A.; Martinac, B.; Grosser, M.; dos Remedios, C. Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease Biophysical Reviews. 2022, 14, 369-379. Article.

     More publications