Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.

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Ying Ge, PhD

Professor, Department of Cell and Regenerative Biology
Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology


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    News and Updates

  • July 2026, Andrew Perciaccante was awarded first place and Ruby Chan won the third place in the Rising Star Competition at the 2026 UW-Madison Human Proteomics Symposium! Congratulations!
  • June 2026, Dr. Holden Rogers defended his thesis and transitioned to a new role at Eli Lilly! We will never fore-get our tee-rific time with him, and we're sure Hoosier life will be a par-tee!
  • May 2026, Huge congratulations to Ruby Chan for receiving the highly prestigious ASMS Graduate Student Award!
  • May 2026, Dr. Zhan Gao was named one of the five postdocs selected for the ASMS Postdoctoral Career Development Award!
  • May 2026, Congratulations to our MD student David Chrisbaum on receiving the Shapiro Research Fellowship! Great job David!
  • May 2026, Matthew Fischer received the 2026 CACA Dr. Andrew Alpert Memorial Travel Grant Award. Congratulations!
  • May 2026, our undergraduate student Jiaqi (Coco) Chen received the highly competitive Wisconsin Hilldale Undergraduate/Faculty Research Fellowship! Congratulations!
  • April 2026, Ryan Schroder received NSF GRFP honorable mention. Good job Ryan!
  • March 2026, Ruby Chan has been selected for the UW-Madison Department of Chemistry Alida and Ronald Anderson Graduate Student award. Congratulations to Ruby!
  • March 2026, congrats to our undergraduate student Jiaqi (Coco) Chen on receiving the Mary Shine Peterson Award! Congrats to Leah GE on receiving the Biochemistry Undergraduate Summer Research Award!
  • February 2026, Congratulations to Holden Rogers on receiving the USHUPO early career investigator award! Great job on being an invited session Chair!

  • December 2025, Hsin-ju (Ruby) Chan received the highly competitive AHA Predoctoral Fellowship! Congratulations!
  • November 2025, Heewon Choi, Fuxuan Liu, and Ryan Schroeder joined our lab from the Chemistry program! Welcome to the Ge Group!
  • September 2025, Holden Rogers received the highly prestigious F31 Fellowship! Congratulations!
  • July 2025, Dr. Kalina Rossler successfully defended her thesis and is now a medical affairs specialist at Exact Sciences. She won't need luck with such a pluripotent skillset!
  • July 2025, Dr. Emily Reasoner successfully defended her thesis and is moving on to North Carolina. Training starts now: it's 'y'all', not 'you guys'!
  • July 2025, Ying was interviewed by The Analytical Scientist about her career path, perspectives on the future of analytical science, and being named on the 2024 Analytical Scientist Power List! [Link]
  • May 2025, Dr. Scott Price successfully graduated from medical school and will be staying at UW Health for his residency. We're so happy you'll be just a couple wings away!
  • April 2025, Holden Rogers received the ASMS Graduate Student Award!
  • March 2025, Holden Rogers received the Gary R. Parr Memorial Award from the Chemistry Department!
  • February 2025, Ruby Chan received the Fourier Transform Mass Spectrometry (FTMS) Conference Award!
  • January 2025, Dr. Emily Chapman successfully defended her thesis and has transitioned to a new job at WisperBio. Taking "New Year, New Me" to the next level!
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Most Recent Publications

  1. Clemmer, I.; Rogers, H.; Wilson, M.; Gao, Z.; Chan, H.-J.; Gregorich, Z.; Raza, F.; Ge, Y. A Streamlined One-Pot Extraction Method Enables High-Sensitivity Top-Down Proteomic Characterization of Phospholamban from Biopsy-Scale Cardiac Tissue. J. Am. Soc. Mass Spectrom. 2026, Accepted.
  2. Krichel, B.; Chan, H.-J.; Bandura, L. J.; Gao, Z.; Wang, M.-D.; Rogers, H. T.; McIlwain, S. J.; Uetrecht, C.; Ge, Y. AMPK Phosphorylation Proceeds Through Hierarchical Proteoform Cascades Revealed by Integrated Mass Spectrometry. Science Adv. 2026. Article
  3. Rogers, H. T.; Gregorich, Z. R.; Gant, M. S.; Gao, Z.; Chamot-Rooke, J.; Ge, Y. Proteoforms in Disease: Biomedical Applications of Top-Down Proteomics. Mass Spectrom. Rev. 2026. Article
  4. Zhang, Y.; Gregorich, Z. R.; Liu, C.; Larson, E. J.; Ge, Y.; Guo, W. Cytoplasmic RBM20 Granules Modulate Non-RBM20 Target Splicing Through Interactions with Other Splicing Factors. Nucleic Acids Res. 2026. Article
  5. Gowda, A. M.; Rogers, H. T.; Ríos Pérez, E. B.; Shenkenberg, S. L.; Ge, Y.; Alvarado, F. J., Loss of Phospholamban Phosphorylation Blunts Ca2+ Handling During the Cellular Adrenergic Response. J. Mol. Cell. Cardiol. 2026. Article
  6. Raza, F.; Gregorich, Z. R.; Freeman, J.; Moore, B.; Houston, T.; Garcia-Arango, M.; et al.; Ge, Y. Multimodal Framework of Left Heart-Pulmonary Vascular Remodeling Underlying Right Ventricular Failure in PH-HFpEF. Circ. Heart Fail. 2026. Article
  7. Wike, C. J.; Alshami, A. S.; Fischer, M. S.; Pullela, A. S.; Ge, Y. MS-Compatible Hydrophobic Interaction Chromatography of Intact Proteins Using Long-Ligand Stationary Phases. J. Chromatogr. A 2026. Article
  8. Towler, A. G.; Wang, F.; Bi, Y.; Bandura, L. J.; Zhu, Y.; Zhu, J.; Perciaccante, A. J.; Aballo, T. J.; Ji, Q. C.; Jin, L.; Buck, W.; Phillips, L.; Kadoya, K.; Schnapp, L. M.; He, Y.; Tian, Y.; Ge, Y. Systematic Quantitative Proteomics Defines Age-, Sex-, and Region-Dependent Remodeling of Lung Extracellular Matrix. bioRxiv 2026. Preprint
  9. Feeney, A. K.; Simmons, A. D.; Bayne, E. F.; Zhu, Y.; Park, C.; Peplinski, C.; Shabnam, F.; Zhang, X.; Zhang, J.; Pergande, M. R.; Kamp, T. J.; Ge, Y.; Palecek, S., Multi-Omic Analysis Reveals Maturation Programs in Human Pluripotent Stem Cell-Derived Cardiomyocytes During Long-Term Culture. bioRxiv 2026. Preprint
  10. Perciaccante, A. J.; Rogers, H. T.; Zhu, Y.; Barnwal, A.; Inman, D.; Wang, M.-D.; Jin, S(); Ponik, S. M.; Ge, Y. Integrated Multi-Omics Enabled by Sequential Extraction for Comprehensive Molecular Profiling of Small Extracellular Vesicles. Anal. Chem. 2026. Article
  11. Saei, A. A.; Ghaffari, B.; Bonakdarpour, B.; Sun, L.; Ge, Y.; Nisbet, D. R.; Serpooshan, V.; Kostarelos, K.; Borhan, B.; Murphy, C. J.; Caruso, F.; Mahmoudi, M., Leveraging Nanoparticle Protein Corona to Advance Plasma Proteome Profiling. Nature Commun. 2026. Article
  12. Gregorich, Z. R.; Gao, Z.; Rossler, K. J.; Ralphe, J. C.; Kamp, T. J.; Ge, Y. Beyond Sarcomere Genetics: Proteomic Insights into Hypertrophic Cardiomyopathy. Biophys. Rev. 2026. Article
  13. Lundby, A.; Van Eyk, J. E.; Mayr, M.; White, M. Y.; Kirk, J. A.; Achter, J. S.; Fert-Bober, J.; Wierer, M.; Mertins, P.; Lam, M. P. Y.; Humphrey, S. J.; Lau, E.; Gramolini, A. O.; Ge, Y.; Gundry, R. L. Consensus Statement on Mass Spectrometry-Based Proteomic Analysis of Cardiac Tissue. Nature Cardiovasc. Res. 2026. Article
  14. Wilson, Mallory C.; Gao, Z.; Lopez, Justin R.; Zhu, Y.; Olszewski, Szczepan S.; Konopka, Adam R.; Diffee, Gary M.; Ge, Y., Top-Down Proteomics of Skinned Human Muscle Fibers Reveals Proteoform-Resolved Fiber-to-Fiber Variability. J. Mass Spectrom. 2026. Article. News Release. Blog Discussion.
  15. Gao, Z.; Clemmer, I.R.; Chan, H.-J.; Osei, K.; Rogers, H.T.; Weir, T.S.; Fischer, M.S.; Gearhart, R.L.; Price, S.J.; Zhu, Y.; Brasier, A.R.; Wu, J.; Zhu, W.; Ge, Y. A Proteoform-Resolved Atlas of Human Cardiac Histones. Research Square, 2026. PrePrint
  16. Feeney, A.K.; Simmons, A.D.; Bayne, E.F.; Zhu, Y.; Pentes, M.R.; Cobra, P.F.; Zhang, J.; Kamp, T.J.; Ge, Y.; Palecek, S.P. Early multi-omic signatures and machine learning models predict cardiomyocyte differentiation efficiency and enable robust hPSC differentiation to cardiomyocytes. bioRxiv, 2026. PrePrint
  17. Gould, N.; Wang, Q.; Agar, J.N.; Brodbelt, J.S.; Chen, D.; Cupp-Sutton, K.A.; Domínguez-Vega, E.; Fang, F.; Fillet, M.; Fischer, M.S.; Gaspar, A.; Ge, Y.; Gou, M.-J.; Greguš, M.; Gstöttner, C.; Hamidli, N.; Helms, A.; Hossain, M.A.; Juetten, K.J.; Kelleher, N.L.; Kraus, T.; Larson, E.J.; Mellors, J.S.; Nagy, C.; Neusüß, C.; Redman, E.A.; Schairer, J.; Wu, S.; Xu, T.; Zhao, Z.; Zhu, G.; Ivanov, A.R.; Jooß, K.; Sun, L. Intact Proteoform Analysis by Capillary Electrophoresis–Mass Spectrometry. Are We There Yet?. Angew. Chem. Int. Ed., 2025. Article
  18. Gao, Z.; Rossler, K.J.; Rogers, H.T.; Gregorich Z.R.; Aballo, T.J.; Chapman, E.A.; Price, S.J.; Hermsen, J.; de Lange, W.J.; Zhu, Y.; Zhang, B.; Chen, J.; Ralphe, J.C.; Kamp, T.J.; Ge, Y., Global Proteoform Alterations Across Multiple Cellular Compartments Underlie Obstructive Hypertrophic Cardiomyopathy. Circ: Heart Failure, 2025. Article
  19. Buck, K. M.; Rogers, H. T.; Gregorich, Z. R.; Mann, M. W.; Aballo, T. J.; Gao, Z.; Chapman, E. A.; Perciaccante, A. J.; Price, S. J.; Lei, I.; Tang, P. C.; Ge, Y. Extracellular matrix alterations in chronic ischemic cardiomyopathy revealed by quantitative proteomics. JCI Insight 2025. Article
  20. Wilson, M. C.; Josvai, M.; Walters, J. K.; Lawson, J.; Rossler, K. J.; Gao, Z.; Zhu, Y.; Kamp, T. J.; Crone, W. C.; Eckhardt, L. L.; Ge, Y., High-Sensitivity Top-Down Proteomics Reveals Enhanced Maturation of Micropatterned Induced Pluripotent Stem Cell-Derived Cardiomyocytes. J. Proteome Res. 2025. Article
  21. Lei, I.; Sicim, H.; Gao, W.; Huang, W.; Noly, P. E.; Pergande, M. R.; Wilson, M. C.; Lee, A.; Liu, L.; Abou El Ela, A.; Jiang, M.; Saddoughi, S. A.; Pober, J. S.; Platt, J. L.; Cascalho, M.; Pagani, F. D.; Chen, Y. E.; Pitt, B.; Wang, Z.; Mortensen, R. M.; Ge, Y.; Tang, P. C. Mineralocorticoid receptor phase separation modulates cardiac preservation. Nat. Cardiovasc. Res. 2025, 4, 710–726. Article
  22. Chan, H.-J.; Krichel, B.; Bandura, L. J.; Chapman, E. A.; Rogers, H. T.; Fischer, M. S.; Roberts, D. S.; Gao, Z.; Wang, M.-D.; Wu, J.; Uetrecht, C.; Jin, S.; Ge, Y. Structural heterogeneity of proteoform-ligand complexes in amp-activated protein kinase uncovered by integrated top-down mass spectrometry. J. Am. Chem. Soc. 2025, 147, 30809–30819 Article
  23. Fischer, M. S.; Rogers, H. T.; Chapman, E. A.; Jin, S.; Ge, Y., Native top-down proteomics of endogenous protein complexes enabled by online two-dimensional liquid chromatography. Anal. Chem. 2025, 97, 25, 13663-13671 Article
  24. Liu, M.; Zhu, Y.; McIlwain, S. J.; Deng, H.; Brasier, A. R.; Ge, Y.; Kimple, M. E.; Baschnagel, A. M., Characterizing Plasma-based Metabolomic Signatures for Metastasis in Non- Small Cell Lung Cancer. Metabolites. 2025. Article
  25. Liu, X.; Roberts, D. S.; Bingman, C. A.; Jin, S.; Ge, Y.; Gellman, S. H., Rational design of a foldon-derived heterotrimer guided by quantitative native mass spectrometry. JACS 2025, 2025.03. 25.645370. Article
  26. Aballo, T. J.; Bae, J.; Paltzer, W. G.; Chapman, E. A.; Perciaccante, A. J.; Pergande, M. R.; Salamon, R. J.; Nuttall, D. J.; Mann, M. W.; Ge, Y., Integrated Proteomics identifies troponin I isoform switch as a Regulator of a Sarcomere-Metabolism Axis during Cardiac Regeneration. Cardiovasc. Res. 2025, cvaf069. Article
  27. Towler, A. G.; Perciaccante, A. J.; Aballo, T. J.; Zhu, Y.; Wang, F.; Lloyd, S.; Kadoya, K.; He, Y.; Tian, Y.; Ge, Y., A Single-Step Protein Extraction for Lung Extracellular Matrix Proteomics Enabled by the Photocleavable Surfactant Azo and timsTOF Pro. Mol. Cell.Proteomics 2025, 100950. Article
  28. Reasoner, E. A.; Chan, H.-J.; Aballo, T. J.; Plouff, K. J.; Noh, S.; Ge, Y.; Jin, S., In Situ Metal–Organic Framework Growth in Serum Encapsulates and Depletes Abundant Proteins for Integrated Plasma Proteomics. ACS nano 2025, 19, 13968–13981. Article
  29. Knott, S. J.; Tucholski, T.; Josyer, H.; Inman, D.; Friedl, A.; Zhu, Y.;; Ge Y.; Ponik, S. M., Deciphering Proteoform Landscape of Mammary Carcinoma by Top-Down Proteomics. J. Proteome Res. 2025, 24, 3, 1425–1438. Article
  30. Chapman, E. A.; Rogers, H. T.; Gao, Z.; Chan, H.-J.; Alvarado, F. J.; Ge, Y., In-depth characterization of S-glutathionylation in ventricular myosin light chain 1 across species by top-down proteomics. J. Mol. Cell. Cardiol. 2025. doi: 10.1016/j.yjmcc.2025.03.012. Online ahead of print. Article
  31. Gregorich, Z.R.; Larson, E.J.; Zhang, Y.; Braz, C.U.; Ge, Y.; Guo, W., Integrated proteomics and transcriptomics analysis reveals insights into differences in premature mortality associated with disparate pathogenic RBM20 variants. J. Mol. Cell. Cardiol., 2024, 197, 78-89. Article
  32. Turner, D.G.P.; De Lange, W. J.; Zhu, Y.; Coe, C.L.; Simcox, J.; Ge, Y.; Kamp, T.J.; Ralphe, J.C.; Glukhov, A.V., Neutral sphingomyelinase regulates mechanotransduction in human engineered cardiac tissues and mouse hearts. J. Physiol., 2024, 602 (18), 4387-4407 Article
  33. Fischer, M.S.; Rogers, H.T.; Chapman, E.A.; Chan, H.; Krichel, B.; Gao, Z.; Larson, E.J.; Ge, Y., Online Mixed-Bed Ion Exchange Chromatography for Native Top-Down Proteomics of Complex Mixtures. J. Proteome Res., 2024, 23 (7), 2315-2322. Article
  34. Roberts, D. S.; Loo, J. A.; Tsybin, Y. O.; Liu, X.; Wu, S.; Chamot-Rooke, J.; Agar, J. N.; Paša-Tolić, L.; Smith, L. M.; Ge, Y., Top-down proteomics. Nature Reviews Methods Primers 2024, 4 (1), 38. Article
  35. Wang, Y.; Zhao, M.; Liu, X.; Xu, B.; Reddy, G. R.; Jovanovic, A.; Wang, Q.; Zhu, C.; Xu, H.; Bayne, E. F.; Xiang, W.; Tilley, D. G.; Ge, Y.; Tate, C. G.; Feil, R.; Chiu, J. C.; Bers, D. M.; Xiang, Y. K., Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure. JACC: Basic to Translational Science 2024. Article
  36. Habeck, T.; Brown, K. A.; Des Soye, B.; Lantz, C.; Zhou, M.; Alam, N.; Hossain, M. A.; Jung, W.; Keener, J. E.; Volny, M.; Wilson, J. W.; Ying, Y.; Agar, J. N.; Danis, P. O.; Ge, Y.; Kelleher, N. L.; Li, H.; Loo, J. A.; Marty, M. T.; Paša-Tolić, L.; Sandoval, W.; Lermyte, F., Top-down mass spectrometry of native proteoforms and their complexes: a community study. Nature Methods 2024. Article
  37. Stroik, D.; Gregorich, Z. R.; Raza, F.; Ge, Y.; Guo, W., Titin: roles in cardiac function and diseases. Front Physiol 2024, 15, 1385821. Article
  38. Anderson, C. L.; Brown, K. A.; North, R. J.; Walters, J. K.; Kaska, S. T.; Wolff, M. R.; Kamp, T. J.; Ge, Y.; Eckhardt, L. L., Global Proteomic Analysis Reveals Alterations in Differentially Expressed Proteins between Cardiopathic Lamin A/C Mutations. Journal of Proteome Research 2024,23 (6), 1970-1982. Article
  39. Wancewicz, B.; Pergande, M. R.; Zhu, Y.; Gao, Z.; Shi, Z.; Plouff, K.; Ge, Y., Comprehensive Metabolomic Analysis of Human Heart Tissue Enabled by Parallel Metabolite Extraction and High-Resolution Mass Spectrometry. Anal Chem 2024,96 (15), 5781-5789. Article
  40. Rossler, K. J.; de Lange, W. J.; Mann, M. W.; Aballo, T. J.; Melby, J. A.; Zhang, J.; Kim, G.; Bayne, E. F.; Zhu, Y.; Farrell, E. T.; Kamp, T. J.; Ralphe, J. C.; Ge, Y., Lactate- and immunomagnetic-purified hiPSC-derived cardiomyocytes generate comparable engineered cardiac tissue constructs. JCI Insight, 2024, Article
  41. Chapman, E. A.; Li, B. H.; Krichel, B.; Chan, H.-J.; Buck, K. M.; Roberts, D. S.; Ge, Y. Native Top-Down Mass Spectrometry for Characterizing Sarcomeric Proteins Directly from Cardiac Tissue Lysate. J. Am. Soc. Spectr. 2024, Article
  42. Bayne, E. F.; Buck, K. M.; Tower, A. G.; Zhu, Y.; Pergande, M. R.; Zhou, T.; Price, S.; Rossler, K. J.; Morales-Tirado, V.; Lloyd, S.; Wang, F.; He, Y.; Tian, Y.; Ge, Y. High-Throughput Extracellular Matrix Proteomics of Human Lungs Enabled by Photocleavable Surfactant and diaPASEF. J Proteome Res 2024, Article
  43. Paltzer, W. G.; Aballo, T. J.; Bae, J.; Flynn, C. G. K.; Wanless, K. N.; Hubert, K. A.; Nuttall, D. J.; Perry, C.; Malawi, R.; Ge, Y.; Mahmoud, A. I., mTORC1 regulates the metabolic switch of postnatal cardiomyocytes during regeneration. J. Mol. Cell. Cardiol. 2024 Article
  44. Rogers, H. T.; Melby, J. A.; Ehlers, L. E.; Fischer, M. S.; Larson, E. J.; Gao, Z.; Rossler, K. J.; Wang, D.; Alpert, A. J.; Ge, Y. Small-Scale Serial Size Exclusion Chromatography (s3SEC) for High Sensitivity Top-Down Proteomics of Large Proteoforms. Anal. Chem. 2024 Article
  45. Chapman, E. A.; Roberts, D. S.; Tiambeng, T. N.; Andrews, J.; Wang, M.-D.; Reasoner, E. A.; Melby, J. A.; Li, B. H.; Kim, D.; Alpert, A. J.; Jin, S.; Ge, Y. Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics. Nature Communications 2023, 14, 8400. Article
  46. Brown, K. A.; Morris, R. K.; Eckhardt, S. J.; Ge, Y.; Gellman, S. H. Phosphorylation Sites of the Gastric Inhibitory Polypeptide Receptor (GIPR) Revealed by Trapped-Ion-Mobility Spectrometry Coupled to Time-of-Flight Mass Spectrometry (TIMS-TOF MS). J. Am. Chem. Soc. 2023, Epub ahead of Print Article
  47. West, K. H. J.; Ma, S. V.; Pensinger, D. A.; Tucholski, T.; Tiambeng, T. N.; Eisenbraun, E. L.; Yehuda, A.; Hayouka, Z.; Ge, Y.; Sauer, J.; Blackwell, H. E. Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in Listeria monocytogenes. Biochemistry. 2023. Article
  48. Lermyte, F.; Habeck, T.; Brown, K.; Des Soye, B.; Lantz, C.; Zhou, M.; Alam, N.; Hossain, M.A.; Jung, W.; Keener, J.; Volny, M.; Wilson, J.; Ying, Y.; Agar, J.; Danis, P.; Ge, Y.; Kelleher, N.; Li, H.; Loo, J.; Marty, M.; Pasa-Tolic, L.; Sandoval, W. Top-down mass spectrometry of native proteoforms and their complexes: A community study. Under review at Nature Portfolio. 2023. PREPRINT
  49. Wancewicz, B.; Zhu, Y.; Fenske, R.J.; Weeks, A.M.; Wenger, K.; Pabich, S.; Daniels, M.; Punt, M.; Nall, R.; Peter, D.C.; Brasier, A.; Cox, E.D.; Davis, D.B.; Ge, Y.; Kimple, M.E. Metformin monotherapy alters the human plasma lipidome independent of clinical markers of glycemic control and cardiovascular disease risk in a type 2 diabetes clinical cohort. Journal of Pharmacology and Experimental Therapeutics. 2023. Article
  50. Yan, J.; Wu, Q.; Maity, M.; Braun, D.R.; Alas, I.; Wang, X.; Ying, X.; Zhu, Y.; Bell, B.A.; Rajski, S.R.; Ge, Y.; Richardson, D.D.; Zhong, W.; Bugni, T.S. Rapid Unambiguous Structure Elucidation of Streptnatamide A, a New Cyclic Peptide Isolated from A Marine-derived Streptomyces sp. Chemistry -A European Journal. 2023. Article
  51. Pergande, M. R.; Osterbauer, K. J.; Buck, K. M.; Roberts, D. S.; Wood, N. N.; Balasubramanian, P.; Mann, M. W.; Rossler, K. J.; Diffee, G. M.; Colman, R. J.; Anderson, R. M.; Ge, Y. Mass Spectrometry-Based Multiomics Identifies Metabolic Signatures of Sarcopenia in Rhesus Monkey Skeletal Muscle. Journal of Proteome Research 2023.Article
  52. Melby, J.A.; Brown, K.A.; Gregorich, Z.R.; Roberts, D.S.; Chapman, E.A.; Ehlers, L.E.; Gao, Z.; Larson, E.J.; Jin, Y.; Lopez, J.R.; Hartung, J.; Zhu, Y.; McIlwain, S.J.; Wang, D.; Guo, W.; Diffee, G.M.; Ge, Y. High sensitivity top-down proteomics captures single muscle cell heterogeneity in large proteoforms. PNAS. 2023, 120(19), e2222081120. Article
  53. Rossler, K.J.; de Lange, W.; Mann, M.W.; Aballo, T.J.; Melby, J.A.; Zhang, J.; Kim, G.; Bayne, E.F.; Zhu, Y.; Farrell, E.T.; Kamp, T.J.; Ralphe, J.C.; Ge, Y. Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs. JCI Insight. 2023. Article
  54. Rogers, H.T.; Roberts, D.S.; Larson, E.J.; Melby, J.A.; Rossler, K.J.; Carr, A.V.; Brown, K.A.; Ge, Y. Comprehensive Characterization of Endogenous Phospholamban Proteoforms Enabled by Photocleavable Surfactant and Top-down Proteomics. Anal. Chem. 2023. Article
  55. Wancewicz, B.; Zhu, Y.; Fenske, R.K.; Weeks, A.M.; Wenger, K.; Pabich, S.; Daniels, M.; Punt, M.; Nall, R.; Peter, D.C.; Brasier, A.; Cox, E.D.; Davis, D.B.; Ge, Y.; Kimple, M. Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort. J. of Pharmacology and Exp. Therapeutics. 2023. Article
  56. Aballo, T. J.; Roberts, D.S.; Bayne, E. F.; Zhu, W.; Walcott, G.; Mahmoud, A. I.; Zhang, J.; Ge, Y. Integrated Proteomics Reveals Alterations in Sarcomere Composition and Developmental Processes during Postnatal Swine Heart Development, J. Mol. Cell. Cardiol. 2023, 176, 33-40 Article
  57. Larson, E.J. ; Pergande, M. R; Moss, M. E.; Rossler, K. J.; Wenger, R. K.; Krichel, B.; Josyer, H.; Melby, J. A.; Roberts, D. S.; Pike, K.; Shi, Z.; Chan, H.; Knight, B.; Rogers, H. T.; Brown, K. A.; Ong, I. M.; Kyowon Jeong, K.; Marty, M.; McIlwain, S. J.; Ge, Y. MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing Bioinformatics 2023, btad359 Article
  58. Mann, M.; Fu, Y.; Xu, X.; Roberts, D.S.; Li, Y.; Zhou, J., Ge, Y.; Brasier, A.R. Bromodomain-containing Protein 4 Regulates Innate Inflammation in Airway Epithelial Cells via Modulation of Alternative Splicing. Front. Immunol., 2023, 14, Article
  59. Chapman, E.; Aballo, J. J.; Melby, J.A.; Zhou, T.; Price, S. J.; Rossler, K. J.; Lei, I.; Tang, P. C.; Ge, Y. Defining the Sarcomeric Proteoform Landscape in Ischemic Cardiomyopathy by Top-down Proteomics, J. Proteome Res. 2023, 22, 931-941 Article
  60. Bayne, E.F.; Rossler, K. J.; Gregorich, Z. R.; Aballo, T. J.; Roberts, D.S.; Chapman, E. A.;Guo, W.; Ralphe, J.C.; Kamp, T.J.; Ge, Y. Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart, J Mol Cell Cardiol 2023, 181, 89-97. Article
  61. Brown, K. A.; Gugger, M. K.; Roberts, D. S.; Moreno, M.; Chae, P. S.; Ge, Y.; Jin, S. Synthesis, Self-Assembly Properties, and Degradation Characterization of a Nonionic Photocleavable Azo-Sulfide Surfactant Family, Langmuir, 2023, DOI: 10.1021/acs.langmuir.2c02820 Article
  62. Wu, Q.; Bell, B.A.; Yan, J.; Chevrette, M.G.; Brittin, N.J.; Zhu, Y.; Chanana, S.; Maity, M.; Braun, D.R.; Wheaton, A.M.; Guzei, I.A.; Ge, Y.; Rajski, S.R.; Thomas, M.G.; Bugni, T.S.; SR Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora. J. Am. Chem. Soc. 2023, 145, 58–69. Article
  63. Brown, K.A.; Gugger, M.; Yu, Z.; Moreno, D.; Jin, S.; Ge, Y. A Nonionic, Cleavable Surfactant for Native Mass Spectrometry and Top-down Proteomics, Anal. Chem. 2023, 95, 1801–1804 Article
  64. Wu, Q.; Bell, B.A.; Yan, J.; Chevrette, M.G.; Brittin, N.J.; Zhu, Y.; Chanana, S.; Maity, M.; Braun, D.R.; Wheaton, A.M.; Guzei, I.A.; Ge, Y.; Rajski, S.R.; Thomas, M.G.; Bugni, T.S.; SR Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora. J. Am. Chem. Soc., 2023, 145, 58–69.Article
  65. Sun M.; Jin Y.; Zhang Y.; Gregorich Z.R.; Ren J.; Ge Y.; Guo W.; SR Protein Kinases Regulate the Splicing of Cardiomyopathy-Relevant Genes via Phosphorylation of the RSRSP Stretch in RBM20. Genes, 2022, 13(9), 1526. Article.
  66. Roberts, D.S.; Mann, M.; Li, B.H.; Kim, D.; Brasier, A.R.; Jin, S. Ge, Y. Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry. Chem. Sci. 2022, 13, 10944-10949. Article.
  67. Larson, E.J.; Gregorich, Z.R.; Zhang, Y.; Li, B.H.; Aballo, T.J.; Melby, J.A.; Ge, Y.; Guo, W. RBM20 Ablation is Associated With Changes in The Expression of Titin-Interacting and Metabolic Proteins. Molecular Omics, 2022. Article.
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