MASH Native is a comprehensive and user-friendly software environment for top-down proteomics, which includes a downloadable software package, MASH Native App, as a versatile, comprehensive platform for top-down proteomics with the capability to process data from various vendor formats and incorporate multiple algorithms for deconvolution and database searching. It is developed by an interdisciplinary team consisting of experts in top-down mass spectrometry-based proteomics, computational data science, and bioinformatics/biostatistics. The Ge lab would like to acknowledge funding from NIH R01 grant (GM125085) to allow the continuous development of MASH Native.

The software is based on our recent developments of MASH Suite, MASH Suite Pro, and MASH Explorer which can process data from various vendors and can incorporate multiple algorithms for deconvolution and database search.

Announcements:

The MASH Team is excited to announce that MASH Native v1.0 is now available! Check it out today [here]

 
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Raw File Formats Include:

Thermo (*.raw) data files
Bruker (*.d and*.ascii) data files
*.mzXML data files
*.mgf data files
Waters data files

    Supported Deconvolution Algorithms:

    Ms-Deconv
    TopFD
    eTHRASH
    pParseTD
    ProMex
    Unidec
    FLASHDeconv

      Supported Database Search:

      MS-Align
      TopPIC
      pTOP
      MSPathFinderT