Most Recent Publications
- Brown, K.A.; Tucholski, T.; Alpert, A.J.; Eken, C.; Wesemann, L.; Kyrvalis, A.; Jin, S.; Ge, Y. Top-Down Proteomics of Endogenous Membrane Proteins Enabled by Cloud Point Enrichment and Multidimensional Liquid Chromatography–Mass Spectrometry, Anal. Chem, 2020, Online ahead of print. Article.
- Styles, M.J.; Early, S.A.; Tucholski, T.; West, K.H.J.; Ge, Y.; Blackwell, H.E. Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor, ACS Infect. Dis., 2020, Online ahead of print. Article.
- Larson, E.J.; Zhu, Y.; Wu, Z.; Chen, B.; Zhang, Z.; Zhou, S.; Han, L.; Zhang, Q.; Ge, Y.; Rapid Analysis of Reduced Antibody Drug Conjugate by Online LC-MS/MS with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal. Chem., 2020, 2020, 92, 22, 15096-15103. Article.
- Zhou, M.; Lantz, C.; Brown, K.A.; Ge, Y.; Pasa-Tolic, L.; Loo, J.A.; Lermyte, F.; Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry, Chem. Science, 2020, Online ahead of print.Article.
- Zhu, Y.; Wancewicz, B.; Schaid, M.; Tiambeng, T.N.; Wenger, K.; Jin, Y.; Heyman, H.; Thompson, C.J.; Barsch, A.; Cox, E.D.; Davis, D.B.; Brasier, A.R.; Kimple, M.; Ge, Y. Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research, J. Proteome Res., 2020, Online ahead of print. Article.
- Tucholski, T.; Cai, W.; Gregorich, Z.R.; Bayne, E.F.; Mitchell, S.D.; McIlwain, S.J.; de Lange, W.J.; Wrobbel, M.; Karp, H.; Hite, Z.; Vikhorev, P.G.; Marston, S.B.; Lal, S.; Li, A.; dos Remedios, C.; Kohmoto, T.; Hermsen, J.; Ralphe, J.C.; Kamp, T.J.; Moss, R.L.; Ge, Y. Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics, Proc Natl Acad Sci USA, 2020, 117 (40), 24691-24700.Article.
- Kellie, J.F.; Tran, J.C.; Jian, W.; Jones, B.; Mehl, J.T.; Ge, Y.; Henion, J.; Bateman, K.P. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective, J. Am. Soc. Mass Spectrom., 2020, Online ahead of print. Article.
- Tucholski, T.; Ge, Y. Fourier‐transform ion cyclotron resonance mass spectrometry for characterizing proteoforms, Mass Spectrom. Rev., 2020, Online ahead of print. Article.
- Tiambeng, T. N.*; Roberts, D.S.*; Brown, K.A.; Zhu, Y.; Chen, B.; Wu, Z.; Mitchell, S.D.; Guardado-Alvarez, T.M.; Jin, Y.; Ge, Y. Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum., Nat Commun., 2020, 11 (1), 1-12. Article.
- Wu, Z.; Roberts, D.S.; Melby, J.A.; Wenger, K.; Wetzel, M.; Gu, Y.; Ramanathan, S.G.; Bayne, E.F.; Liu, X.; Sun, R.; Ong, I.M.; McIlwain, S.J.; Ge, Y. MASH Explorer: A Universal Software Environment for Top-Down Proteomics., J. Proteome Res., 2020, 19, 9, 3867–3876. Article.
- Srzentic, K.; Fornelli, L.; Tsybin, Y.O.; Loo, J.A.; Seckler, H.; Agar, J.N.; Anderson, L.C.; Bai, D.L.; Beck, A.; Brodbelt, J.S.; van der Burgt, Y.E.M.; Chamot-Rooke, J.; Chatterjee, S.; Chen, Y.; Clarke, D.J.; Danis, P.O.; Diedrich, J.K.; D'Ippolito, R.A.; Dupré, M.; Gasilova, N.; Ge, Y.; Ah Goo, Y.; Goodlett, D.R.; Greer, S.M.; Haselmann, K.F.; He, L.; Hendrickson, C.L.; Hinkle, J.D.; Holt, M.; Hughes, S.; Hunt, D.F.; Kelleher, N.L.; Kozhinov, A.N.; Lin, Z.; Malosse, C.; Marshall, A.G.; Menin, L.; Millikin, R.J.; Nagornov, K.O.; Nicolardi, S.; Paša-Tolić, L.; Pengelley, S.; Quebbemann, N.R.; Resemann, A.; Sandoval, W.; Sarin, R.; Schmitt, N.D.; Shabanowitz, J.; Shaw, J.B.; Shortreed, M.R.; Smith, L.M.; Sobott, F.; Suckau, D.; Toby, T.; Weisbrod, C.R.; Wildburger, N.C.; Yates, J.R.; Yoon, S.H.; Young, N.L.; Zhou, M. Inter-laboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2020, 31, 9, 1783–1802. Article.
- Xu, B.; Li, M.; Wang, Y.; Zhao, M.; Morotti, S.; Shi, Q.; Wang, Q.; Barbagallo, F.; Teoh, J.; Reddy, G.R.; Bayne, E.F.; Liu, Y.; Shen, A.; Puglisi, J.L. Ge, Y.; Li, J.; Grandi, E.; Nieves-Cintron, M.; Xiang, Y.K. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failureβ, Circ Res., 2020, 127, 796–810. Article.
- McIlwain, S.; Wu, Z.; Wetzel, M.; Belongia, D.; Jin, Y.; Wenger, K.; Ong, I.; Ge, Y. Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy., J. Am. Soc. Mass Spectrom., 2020, 31(5), 1104-1113. Article.
- Brown, K; Tucholski, T; Eken, C; Knott, S; Zhu, Y; Jin, S; Ge, Y. High-throughput Proteomics Enabled by a Photocleavable Surfactant., Angew Chem Int Ed Engl., 2020, 59(22), 8406-8410. Article.
- Zhang, F; Wyche, TP; Zhu, Y; Braun, DR; Yan, JX; Chanana, S; Ge, Y.; Guzei, IA; Chevrette, MG; Currie, CR; Thomas, MG; Rajski, SR; Bugni, TS.; MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product., Org Lett., 2020, 22(4), 1275-1279. Article.
- Melby, J. A.; Jin, Y.; Lin, Z.; Tucholski, T.; Wu, Z.; Gregorich, Z. R.; Diffee, G. M.; Ge, Y. Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues., J. Proteome Res., 2020,19(1), 443–454. (Article selected for cover of Jan. issue) Article.
- Bortnov, V.; Tonelli, M.; Lee, W.; Lin, Z.; Annis, D. S.; Demerdash, O.; Bateman, A.; Mitchell, J.; Ge, Y.; Markley, J. L.; Mosher, D. F. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum, Nature Commun., 2019, 10, 1-14. Article.
- Cai, W.; Zhang, J.; De Lange, W. J.; Gregorich, Z. R.; Karp, H.; Ferrell, E. T.; Mitchell, S. T.; Tucholski, T.; Lin, Z.; Biermann, M.; McIlwain, S.; Ralphe, J. C.; Kamp, T. J.; Ge, Y. Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes., Circ Res., 2019, 125, 936–953. Article.
- Tiambeng, T. N.; Tucholski, T.; Wu, Z.; Zhu, Y.; Mitchell, S. D.; Roberts, D. S.; Jin, Y.; Ge, Y. Analysis of cardiac troponin proteoforms by top-down mass spectrometry, Methods Enzymol., ISSN 0076-6879 Article.
- Wu, Z.; Jin, Y.; Chen, B.; Gugger, M. K.; Wilkinson-Johnson, C. L.; Tiambeng, T. N.; Jin, S.; Ge, Y., Comprehensive Characterization of Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry, J. Am. Soc. Mass Spectrom., 2019, 30, 2561-2570. Article.
- Smith, L. M.; Thomas, P. M.; Shortreed, M. R.; Scheffer, L. V.; Fellers, R. T.; LuDec, R. D.; Tucholski, T.; Ge, Y.; Agar, J. N.; Anderson, L. C.; Chamot-Rooke, J.; Gault, J.; Loo, J. A.; Pasa-Tolic, L.; Robinson, C. V.; Schluter, H.; Tsybin, Y. O.; Vilaseca, M.; Vizcaino, J. A.; Danis, P. O.; Kelleher, N. L., A five-level classification system for proteoform identifications, Nature Methods. 2019, 16, 939-940. Article.
- Chen, B.; Lin, Z.; Zhu, Y.; Jin, Y.; Larson, E.; Xu, Q.; Fu, C.; Zhang, Z.; Zhang, Q.; Pritts, W. A.; Ge, Y. Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation., Anal Chem. 2019, 16, 18, 11661-11669. Article.
- Schaffer, L. A.; Tucholski, T.; Shortreed, M. R.; Ge, Y.; Smith, L. M., Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms., Anal Chem. 2019, 19, 10937-10942. Article.
- Biermann, M.; Cai, W.; Lang, D.; Hermsen, J.; Profio, L.; Zhou, Y.; Czirok, A.; Isai, D. G.; Napiwocki, B. N.; Rodriguez, A. M.; Brown, M. E.; Woon, M. T.; Shao, A.; Han, T.; Park, D.; Hacker, T. A.; Crone, W. C.; Burlingham, W. J.; Glukhov, A. V.; Ge, Y.; Kamp, T. J., Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation, Stem Cells. 2019, 37, 910-923. Article.
- Brown, K. A.; Chen, B.; Guardado-Alvarez, T. M.; Lin, Z.; Hwang, L.; Ayaz-Guner, S.; Jin, S.; Ge, Y. A Photocleavable Surfactant for Top-Down Proteomics, Nature Methods. 2019, 16, 417-420. News Release.
- Donnelly, D. P.; Rawlins, C. M.; DeHart, C. J.; Fornelli,, L.; Schachner, L. F.; Lin, Z.; Lippens, J. L.; Aluri, K. C.; Sarin, R.; Chen, B.; Lantz, C.; Jung, W.; Johnson, K. R.; Koller, A.; Wolff, J. J.; Campuzano, I. D. G.; Auclair, J. R.; Ivanov, A. R.; Whitelegge, J. P.; Paša-Tolić, L.; Chamot-Rooke, J.; Danis, P. O.; Smith, L. M.; Tsybin, Y. O.; Loo, J. A.; Ge Y.; Kelleher N. L.; Agar J. N. Best practices and benchmarks for intact protein analysis for top-down mass spectrometry., Nature Methods. 2019, 16, 587-594. Article.
- Schaffer, L. V.; Millikin, R. J.; Miller, R. M.; Anderson, L. C.; Fellers R. T.; Ge Y.; Kelleher N. L.; LeDuc R. D.; Liu X.; Payne, S. H.; Sun, L.; Thomas, P. M.; Tucholski, T.; Wang, Z.; Wu, S.; Wu, Z.; Yu, D.; Shortreed, M. R.; Smith, L. M. Identification and Quantification of Proteoforms by Mass Spectrometry, Proteomics, 2019, 19, 1800361 Article.
- Roberts, D. S.; Chen, B.; Tiambeng, T. N.; Wu, Z.; Ge, Y.; Jin, S. Reproducible large-scale synthesis of surface silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the human heart phosphoproteome, Nano Res., 2019, 12, 1473-1481. DOI: 10.1007/s12274-019-2418-4. Article.
- Jin, Y.; Diffee, G. M.; Colman, R. J.; Anderson, R. M.; Ge, Y. Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle, J. Am. Soc. Mass Spectrom. 2019. Epub ahead of print. DOI: 10.1007/s13361-019-02139-0 Article
- Tucholski, T.; Knott, S.; Chen, B.; Pistono, P.; Lin, Z.; Ge, Y. A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal Chem., 2019, 91, 3855-3844. DOI: 10.1021/acs.analchem.8b04082. Article
- Liang, Y.; Jin, Y.; Wu, Z.; Tucholski, T.; Brown, K.A.; Zhang, L.; Zhang, Y.; Ge, Y. Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-down Proteomics, Anal Chem., 2019, 91, 3, 1743-1747. DOI: 10.1021/acs.analchem.8b05817. Article
- Gregorich, Z.R.; Patel, J.R.; Cai, W.; Lin, Z.; Heurer, R.; Fitzsimons, D.P.; Moss, R.L.; Ge, Y. Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium, J Gen Physiol., 2019. PII: jgp.201812214. DOI: 10.1085/jgp.201812214. Article
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